Nuf2 Gene Summary [Mouse]
Predicted to enable microtubule binding activity. Predicted to be involved in kinetochore organization; mitotic spindle organization; and nuclear chromosome segregation. Predicted to be located in cytosol; kinetochore; and nucleoplasm. Predicted to be part of Ndc80 complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma and pancreatic cancer. Orthologous to human NUF2 (NUF2 component of NDC80 kinetochore complex). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nuf2 |
| Official Name | NUF2, NDC80 kinetochore complex component [Source:MGI Symbol;Acc:MGI:1914227] |
| Ensembl ID | ENSMUSG00000026683 |
| Bio databases IDs | |
| Aliases | NUF2, NDC80 kinetochore complex component |
| Synonyms | 2410003C07Rik, CDCA1, CT106, NUF2 component of NDC80 kinetochore complex, NUF2, NDC80 kinetochore complex component, NUF2R |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nuf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- Nuf2 family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- epithelial neoplasia
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- Wilms tumor
- Wilms tumorigenesis
- osteosarcomagenesis
- organismal death
- lung adenocarcinoma
role in cell
- apoptosis
- cell death
- phosphorylation in
- proliferation
- expression in
- cell viability
- tension
- migration
- attachment
- Clathrin mediated endocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nuf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- mitotic cell cycle spindle assembly checkpoint
- mitotic spindle organization
- kinetochore organization
- meiotic chromosome segregation
- attachment of spindle microtubules to kinetochore
- chromosome segregation
- attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation
Cellular Component
Where in the cell the gene product is active
- Ndc80 complex
- membrane
- cytosol
- kinetochore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- microtubule binding