Inpp5f Gene Summary [Mouse]
Enables inositol monophosphate 4-phosphatase activity and phosphatidylinositol phosphate 4-phosphatase activity. Involved in several processes, including negative regulation of axon regeneration; phosphatidylinositol dephosphorylation; and positive regulation of receptor recycling. Acts upstream of or within cardiac muscle hypertrophy in response to stress; phosphatidylinositol 3-kinase/protein kinase B signal transduction; and phosphatidylinositol catabolic process. Located in several cellular components, including cytoplasmic vesicle; dendrite; and neuronal cell body. Is expressed in several structures, including brain; genitourinary system; heart; retina; and spleen. Orthologous to human INPP5F (inositol polyphosphate-5-phosphatase F). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Inpp5f |
| Official Name | inositol polyphosphate-5-phosphatase F [Source:MGI Symbol;Acc:MGI:2141867] |
| Ensembl ID | ENSMUSG00000042105 |
| Bio databases IDs | |
| Aliases | inositol polyphosphate-5-phosphatase F |
| Synonyms | 5830435P03Rik, cI-27, hSAC2, inositol polyphosphate-5-phosphatase F, LOC103690084, mKIAA0966, MSTP007, MSTPO47, SAC2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Inpp5f often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
- Inositol phosphatase
- inositol-polyphosphate 5-phosphatase
- phosphatase
- protein homodimerization
- inositol-1(or 4)-monophosphatase
- protein binding
- phosphoinositide 5-phosphatase
- SacI homology domain
Pathways
Biological processes and signaling networks where the Inpp5f gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- liver cancer
- hepatocellular carcinoma
- Parkinson disease
- organismal death
- chronic lymphocytic leukemia
- REM sleep behavior disorder
- non-insulin-dependent diabetes mellitus
- dystrophy
role in cell
- accumulation in
- expression in
- proliferation
- growth
- regeneration
- upregulation in
- regeneration in
- growth in
- reformation
- reformation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- Cytoplasm
- endosomal membrane
- recycling endosomes
- early endosomes
- endocytotic vesicle
- clathrin-coated pits
- membrane processes
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Inpp5f gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylinositol catabolic process
- adult locomotory behavior
- phosphatidylinositol biosynthetic process
- negative regulation of tyrosine phosphorylation of STAT protein
- phosphatidylinositol dephosphorylation
- clathrin-mediated endocytosis
- regulation of protein kinase B signaling cascade
- protein kinase B signaling cascade
- negative regulation of axon regeneration
- positive regulation of receptor recycling
- phosphatidylinositol-mediated signaling
- negative regulation of peptidyl-serine phosphorylation
- regulation of cell motility
- cardiac muscle hypertrophy in response to stress
- regulation of endocytic recycling
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- dendrite
- early endosome
- intracellular membrane-bounded organelle
- coated pit
- recycling endosome
- clathrin-coated endocytic vesicle
- neuronal cell body
- axon
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4-phosphate phosphatase activity
- protein binding
- inositol monophosphate 1-phosphatase activity
- protein homodimerization activity
- phosphatidylinositol phosphate 4-phosphatase activity
- phosphatidylinositol phosphate 5-phosphatase activity
- inositol monophosphate 3-phosphatase activity
- inositol monophosphate 4-phosphatase activity