Wiz Gene Summary [Mouse]
Enables SET domain binding activity and histone methyltransferase binding activity. Predicted to be involved in positive regulation of nuclear cell cycle DNA replication; protein stabilization; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; palatal shelf; and retina. Orthologous to human WIZ (WIZ zinc finger). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Wiz |
| Official Name | widely-interspaced zinc finger motifs [Source:MGI Symbol;Acc:MGI:1332638] |
| Ensembl ID | ENSMUSG00000024050 |
| Bio databases IDs | |
| Aliases | widely-interspaced zinc finger motifs |
| Synonyms | widely-interspaced zinc finger motifs, WIZ zinc finger, ZNF803 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wiz often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- binding protein
- double-stranded DNA binding
- nucleic acid binding
- enzyme binding
- transcription factor binding
- protein domain specific binding
- protein binding
- zinc finger domain
- sequence-specific DNA binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- midbody
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wiz gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA replication involved in S phase
- protein stabilization
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- midbody
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity