Spc24 Gene Summary [Mouse]
Predicted to contribute to microtubule binding activity. Predicted to be involved in attachment of spindle microtubules to kinetochore. Predicted to be located in kinetochore; nucleolus; and nucleoplasm. Predicted to be part of Ndc80 complex. Is expressed in brain ventricular layer and cerebral cortex. Orthologous to human SPC24 (SPC24 component of NDC80 kinetochore complex). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spc24 |
| Official Name | SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1914879] |
| Ensembl ID | ENSMUSG00000074476 |
| Bio databases IDs | |
| Aliases | SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) |
| Synonyms | 2410030K01RIK, RGD1307631, SPBC24, SPC24 component of NDC80 kinetochore complex, SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae), Spc24-ps1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spc24 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Spc24 subunit of Ndc80
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- organismal death
- coronary artery disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- myocardial infarction
- angina pectoris
- hemorrhoid
role in cell
- attachment
- misalignment in
- misalignment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spc24 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- mitotic cell cycle spindle assembly checkpoint
- attachment of spindle microtubules to kinetochore
- chromosome segregation
Cellular Component
Where in the cell the gene product is active
- Ndc80 complex
- cytosol
- kinetochore
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- microtubule binding