Ints8 Gene Summary [Mouse]
Predicted to be involved in snRNA 3'-end processing. Predicted to be part of integrator complex. Is expressed in cerebral cortex intermediate zone; cerebral cortex subventricular zone; cerebral cortex ventricular layer; and cortical plate. Orthologous to human INTS8 (integrator complex subunit 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ints8 |
| Official Name | integrator complex subunit 8 [Source:MGI Symbol;Acc:MGI:1919906] |
| Ensembl ID | ENSMUSG00000040738 |
| Bio databases IDs | |
| Aliases | integrator complex subunit 8 |
| Synonyms | 2810013E07RIK, C8orf52, D130008D20Rik, INT8, integrator complex subunit 8, NEDCHS, RGD1310592 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ints8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ints8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- snRNA processing
- regulation of transcription elongation from RNA polymerase II promoter
- snRNA 3'-end processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
- integrator complex
Molecular Function
What the gene product does at the molecular level
- protein binding