Ffar1 Gene Summary [Mouse]
Enables bioactive lipid receptor activity. Involved in several processes, including glucose homeostasis; ligand-gated ion channel signaling pathway; and positive regulation of transport. Acts upstream of or within insulin secretion. Located in plasma membrane. Is expressed in gut and male reproductive gland or organ. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human FFAR1 (free fatty acid receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ffar1 |
| Official Name | free fatty acid receptor 1 [Source:MGI Symbol;Acc:MGI:2684079] |
| Ensembl ID | ENSMUSG00000044453 |
| Bio databases IDs | |
| Aliases | free fatty acid receptor 1 |
| Synonyms | FFA1R, free fatty acid receptor 1, GPCR40, GPR40 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ffar1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- bioactive lipid receptor
- fatty acid binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Ffar1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- fibrosis
- hepatic steatosis
- hypertriglyceridemia
- osteoporosis
role in cell
- expression in
- proliferation
- activation in
- phosphorylation in
- differentiation
- formation in
- induction in
- function
- insulin secretion in
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ffar1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- insulin secretion
- negative regulation of interleukin-1 beta production
- positive regulation of calcium ion transport
- glucose homeostasis
- response to fatty acid
- positive regulation of insulin secretion
- phospholipase C-activating G-protein coupled receptor signaling pathway
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- lipid binding
- bioactive lipid receptor activity