Irgq Gene Summary [Mouse]
Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in positive regulation of autophagy; protein quality control for misfolded or incompletely synthesized proteins; and substrate localization to autophagosome. Predicted to be active in autophagosome and lysosome. Is expressed in cortical plate. Orthologous to human IRGQ (immunity related GTPase Q). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Irgq |
| Official Name | immunity-related GTPase family, Q [Source:MGI Symbol;Acc:MGI:2667176] |
| Ensembl ID | ENSMUSG00000041037 |
| Bio databases IDs | |
| Aliases | immunity-related GTPase family, Q |
| Synonyms | FKSG27, immunity-related GTPase family, Q, immunity-related GTPase Q, IRGQ1, RGD1309409 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Irgq often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- lysosome
- autophagic vacuoles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Irgq gene, providing context for its role in the cell.
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding