Elovl6 Gene Summary [Mouse]
Enables acyltransferase activity, transferring groups other than amino-acyl groups. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within fatty acid elongation. Located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ELOVL6 (ELOVL fatty acid elongase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Elovl6 |
| Official Name | ELOVL family member 6, elongation of long chain fatty acids (yeast) [Source:MGI Symbol;Acc:MGI:2156528] |
| Ensembl ID | ENSMUSG00000041220 |
| Bio databases IDs | |
| Aliases | ELOVL family member 6, elongation of long chain fatty acids (yeast) |
| Synonyms | Elongase 6, ELOVL fatty acid elongase 6, FACE, FAE, hELO2, LCE, Lce2, LOC100910695, LOC102549542, long CHAIN FATTY ACYL ELONGASE, RELO2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Elovl6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GNS1/SUR4 family
- fatty acid elongase
- enzyme
- protein binding
- Non-amino-acyl group acyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- breast cancer
- multiple sclerosis
- insulin resistance
- attention deficit hyperactivity disorder
- androgenic alopecia
- nonalcoholic steatohepatitis
- benign prostatic hyperplasia
role in cell
- proliferation
- expression in
- migration
- adipogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Elovl6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- unsaturated fatty acid biosynthetic process
- long-chain fatty acid biosynthetic process
- long-chain fatty-acyl-CoA biosynthetic process
- very long-chain fatty acid biosynthetic process
- fatty acid elongation, saturated fatty acid
- fatty acid elongation, polyunsaturated fatty acid
- fatty acid elongation, monounsaturated fatty acid
- sphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
- fatty acid elongase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- fatty acid elongase activity