Arhgap12 Gene Summary [Mouse]
Predicted to enable GTPase activator activity. Predicted to be involved in several processes, including negative regulation of small GTPase mediated signal transduction; phagocytosis, engulfment; and small GTPase-mediated signal transduction. Predicted to be located in phagocytic cup. Predicted to be active in cytoplasm and plasma membrane. Is expressed in bladder; gut; nervous system; sensory organ; and skeleton. Orthologous to human ARHGAP12 (Rho GTPase activating protein 12). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgap12 |
| Official Name | Rho GTPase activating protein 12 [Source:MGI Symbol;Acc:MGI:1922665] |
| Ensembl ID | ENSMUSG00000041225 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 12 |
| Synonyms | 2810011M08RIK, Rho GTPase activating protein 12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgap12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- Domain with 2 conserved Trp (W) residues
- WW class II binding domain
- WW
- PH domain
- Linker region between SH3 and WW domains on ARHGAP12
- protein binding
- Pleckstrin homology-like domain
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
- WW domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Arhgap12 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- adult T-cell leukemia/lymphoma
regulates
- lactic acid
- D-glucose
- adenosine triphosphate
role in cell
- production in
- generation in
- organization
- glycolysis in
- doxorubicin resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- phagocytic cups
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgap12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phagocytosis, engulfment
- negative regulation of small GTPase mediated signal transduction
- signal transduction
- regulation of GTPase activity
- actin filament organization
- morphogenesis of an epithelial sheet
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- phagocytic cup
Molecular Function
What the gene product does at the molecular level
- GTPase activator activity