Sytl3 Gene Summary [Mouse]
Enables calcium-dependent phospholipid binding activity and neurexin family protein binding activity. Acts upstream of or within exocytosis. Located in plasma membrane. Is expressed in several structures, including genitourinary system; hemolymphoid system; liver; lung; and olfactory epithelium. Orthologous to human SYTL3 (synaptotagmin like 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sytl3 |
| Official Name | synaptotagmin-like 3 [Source:MGI Symbol;Acc:MGI:1933367] |
| Ensembl ID | ENSMUSG00000041831 |
| Bio databases IDs | |
| Aliases | synaptotagmin-like 3 |
| Synonyms | A430092N21, EXOPHILIN 6, Gm2833, mFLJ00307, RGD1561992, SLP3, Slp3-b, synaptotagmin-like 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sytl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- phospholipid binding
- Protein present in Fab1, YOTB, Vac1, and EEA1
- neurexin binding
- calcium-dependent phospholipid binding
- PHD finger superfamily
- linker domain
- protein binding
- Slp homology domain
- Protein kinase C conserved region 2 (CalB)
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- vesicles
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sytl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intracellular protein transport
- exocytosis
Cellular Component
Where in the cell the gene product is active
- exocytic vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- neurexin family protein binding
- small GTPase binding
- calcium-dependent phospholipid binding