Ms4a2 Gene Summary [Mouse]
This gene encodes a member of the membrane-spanning 4A family. The encoded protein is the beta subunit of the high affinity IgE receptor and is localized to the membrane. The encoded protein is required for full activation of mast cells, including the release of histamine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Details
| Type | Protein Coding |
| Official Symbol | Ms4a2 |
| Official Name | membrane-spanning 4-domains, subfamily A, member 2 [Source:MGI Symbol;Acc:MGI:95495] |
| Ensembl ID | ENSMUSG00000024680 |
| Bio databases IDs | |
| Aliases | membrane-spanning 4-domains, subfamily A, member 2 |
| Synonyms | APY, ATOPY, Fce1b, Fc epsilon ri beta, FCER1B, FCERI, FCIGA, FcMR I β Chain, FcRB, Fcrbeta, FcR β, Fc ε ri β, High affinity immunoglobulin ε receptor β subunit, Ige fc receptor β subunit, IGEL, IGER, IGHER, membrane spanning 4-domains A2, membrane-spanning 4-domains, subfamily A, member 2, MS4A1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ms4a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- cytoplasmic domain
- SH2-domain binding
- phosphoprotein binding
- protein binding
- membrane-proximal domain
- IgE receptor
- CD20-like family
- transmembrane receptor
- IgE binding
Pathways
Biological processes and signaling networks where the Ms4a2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cystic fibrosis
- childrens interstitial lung disease
- allergic asthma
- chronic rhinosinusitis with nasal polyps
- angioedema
- asthma
- food allergy
- chronic idiopathic urticaria
- IgE-mediated food allergy
- chronic urticaria
role in cell
- apoptosis
- transactivation in
- phosphorylation in
- degranulation
- reorganization
- function
- reorganization in
- translocation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- endosomes
- cytoplasmic face of plasma membrane
- plasma membrane extracellular face
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ms4a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- cell surface receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- Fc-epsilon receptor I complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- IgE binding