Kif5b Gene Summary [Mouse]
Predicted to enable several functions, including ATP hydrolysis activity; JUN kinase binding activity; and microtubule lateral binding activity. Involved in positive regulation of GABAergic synaptic transmission; regulation of modification of synapse structure, modulating synaptic transmission; and stress granule disassembly. Acts upstream of or within several processes, including cellular response to type II interferon; mitocytosis; and organelle transport along microtubule. Located in several cellular components, including ciliary rootlet; mitochondrion; and phagocytic vesicle. Is active in postsynaptic cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human KIF5B (kinesin family member 5B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kif5b |
| Official Name | kinesin family member 5B [Source:MGI Symbol;Acc:MGI:1098268] |
| Ensembl ID | ENSMUSG00000006740 |
| Bio databases IDs | |
| Aliases | kinesin family member 5B |
| Synonyms | HEL-S-61, Khc, Khc-b, Khcs, KINESIN 1, KINESIN 1 HEAVY CHAIN, kinesin family member 5B, KINH, KNS, KNS1, UKHC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kif5b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Actin interacting protein 3
- Myosin and Kinesin motor domain
- Synaptonemal complex protein 1 (SCP-1)
- helix-rich Mycoplasma protein
- coiled-coil domain
- JUN kinase binding
- protein binding
- motor domain
- identical protein binding
- microtubule motor protein
- Kinesin motor, catalytic domain
- microtubule binding
- binding protein
- stalk region
- Kinesin motor domain
- tail domain
- Intermediate filament protein
- Septation ring formation regulator, EzrA
- middle stalk coils
- cargo binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- myeloid/lymphoid neoplasm with eosinophilia
- hematological neoplasia
- osteogenesis imperfecta
- passive systemic anaphylaxis
- hypertrophic cardiomyopathy
- bipolar disorder
- habitual abortion
role in cell
- expression in
- activation in
- phosphorylation in
- binding in
- differentiation
- aggregation in
- formation
- transmembrane potential
- maturation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- microtubule cytoskeleton
- axon component
- organelle
- perinuclear region
- vesicles
- centrosome
- Mitochondria
- cytosol
- ciliary rootlet
- nuclear envelope
- growth cone
- neurites
- endocytotic vesicle
- beta-granules
- axons
- dendrites
- phagosomes
- mossy fibers
- detergent-soluble fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kif5b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of synaptic transmission, GABAergic
- axon guidance
- positive regulation of potassium ion transport
- natural killer cell mediated cytotoxicity
- microtubule-based movement
- cytoplasm organization
- centrosome localization
- lysosome localization
- plus-end-directed vesicle transport along microtubule
- regulation of membrane potential
- stress granule disassembly
- synaptic vesicle transport
- mitochondrion transport along microtubule
- vesicle transport along microtubule
- cellular response to interferon-gamma
Cellular Component
Where in the cell the gene product is active
- ciliary rootlet
- perinuclear region of cytoplasm
- centriolar satellite
- dendrite cytoplasm
- mitochondrion
- membrane
- phagocytic vesicle
- cytosol
- vesicle
- kinesin complex
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- identical protein binding
- microtubule motor activity
- protein binding
- cadherin binding
- plus-end-directed microtubule motor activity
- microtubule binding