Rapgef5 Gene Summary [Mouse]
Predicted to enable GTP-dependent protein binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in nuclear body. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; heart and pericardium; and sensory organ. Orthologous to human RAPGEF5 (Rap guanine nucleotide exchange factor 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rapgef5 |
| Official Name | Rap guanine nucleotide exchange factor (GEF) 5 [Source:MGI Symbol;Acc:MGI:2444365] |
| Ensembl ID | ENSMUSG00000041992 |
| Bio databases IDs | |
| Aliases | Rap guanine nucleotide exchange factor (GEF) 5 |
| Synonyms | 4932413M22, D030051B22Rik, GFR, LOC100361497, LOC285936, mKIAA0277, mmr-gef, MR-GEF, Rap guanine nucleotide exchange factor 5, Rap guanine nucleotide exchange factor (GEF) 5, Related to Epac, REPAC, RGD1562891, rMR-GEF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rapgef5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
- DEP
- GTP-dependent protein binding
- catalytic domain
- guanyl-nucleotide exchange factor
- protein binding
- RasGEF
- REM
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioblastoma
- glaucoma
- diabetic nephropathy
- glioblastoma cancer
- major depression
- acute tonsillitis
- dilated cardiomyopathy 1A
- osteonecrosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rapgef5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- small GTPase mediated signal transduction
- nervous system development
- Ras protein signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- guanyl-nucleotide exchange factor activity
- GTP-dependent protein binding