Mras Gene Summary [Mouse]
Predicted to enable GTP-dependent protein binding activity; GTPase activity; and guanyl ribonucleotide binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be part of protein phosphatase type 1 complex. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; branchial arch; future spinal cord; limb bud; and liver. Human ortholog(s) of this gene implicated in Noonan syndrome 11. Orthologous to human MRAS (muscle RAS oncogene homolog). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mras |
| Official Name | muscle and microspikes RAS [Source:MGI Symbol;Acc:MGI:1100856] |
| Ensembl ID | ENSMUSG00000032470 |
| Bio databases IDs | |
| Aliases | muscle and microspikes RAS |
| Synonyms | 2900078C09RIK, muscle and microspikes RAS, muscle RAS oncogene homolog, NS11, Ras3, R-RAS3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mras often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding domain
- GTP-dependent protein binding
- membrane-association domain
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- enzyme
- protein binding
- effector domain
- Ras subfamily of RAS small GTPases
- CAAX box
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Mras gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Agrin Interactions at Neuromuscular Junction
- Angiopoietin Signaling
- Apelin Muscle Signaling Pathway
- Bladder Cancer Signaling
- Ceramide Signaling
- CXCR4 Signaling
- ERK5 Signaling
- Estrogen-Dependent Breast Cancer Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Glucocorticoid Receptor Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- Macropinocytosis Signaling
- Mouse Embryonic Stem Cell Pluripotency
- Neuregulin Signaling
- NF-κB Activation by Viruses
- Oncostatin M Signaling
- PPAR Signaling
- Prolactin Signaling
- Renal Cell Carcinoma Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Systemic Lupus Erythematosus Signaling
- Thyroid Cancer Signaling
- UVC-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- non-insulin-dependent diabetes mellitus
- Noonan syndrome type 11
- nonalcoholic steatohepatitis
- myocardial infarction
- Noonan spectrum disorder
- Noonan syndrome
- cardiovascular disorder
- sporadic amyotrophic lateral sclerosis
role in cell
- migration
- expression in
- proliferation
- binding in
- apoptosis
- survival
- quantity
- formation
- growth
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- membrane ruffles
- pseudopodia
- microspikes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mras gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Ras protein signal transduction
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- small monomeric GTPase activity
- GDP binding
- GTP-dependent protein binding