Dnaaf6b Gene Summary [Mouse]
Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in flagellated sperm motility; inner dynein arm assembly; and outer dynein arm assembly. Predicted to be located in trans-Golgi network. Predicted to be active in cytoplasm. Is expressed in brain; lung; oviduct; and testis. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 36. Orthologous to human DNAAF6 (dynein axonemal assembly factor 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnaaf6b |
| Official Name | dynein axonemal assembly factor 6B [Source:MGI Symbol;Acc:MGI:3607720] |
| Ensembl ID | ENSMUSG00000042433 |
| Bio databases IDs | |
| Aliases | dynein axonemal assembly factor 6B |
| Synonyms | CILD36, CXorf41, Dnaaf6b, dynein axonemal assembly factor 6, E230019M04Rik, NYSAR97, PIH1D3, Pih1h3b, TWISTER |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnaaf6b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PIH1 CS-like domain
- dynein intermediate chain binding
- protein binding
- chaperone binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnaaf6b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- outer dynein arm assembly
- sperm motility
- axonemal dynein complex assembly
- cilium movement
- inner dynein arm assembly
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- chaperone binding
- dynein intermediate chain binding