Cdkl3 Gene Summary [Mouse]
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within dendrite extension; negative regulation of axon extension; and positive regulation of dendrite morphogenesis. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human CDKL3 (cyclin dependent kinase like 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdkl3 |
| Official Name | cyclin-dependent kinase-like 3 [Source:MGI Symbol;Acc:MGI:2388268] |
| Ensembl ID | ENSMUSG00000020389 |
| Bio databases IDs | |
| Aliases | cyclin-dependent kinase-like 3 |
| Synonyms | AI852479, B230379H01Rik, cyclin-dependent kinase-like 3, LOC103693326, LOC103694901, NKIAMRE, Nkiatre, NKIATREB |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdkl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- leukemia
- renal clear cell adenocarcinoma
- renal clear cell cancer
- spontaneous preterm birth
role in cell
- expression in
- colony formation by
- morphogenesis
- growth
- survival
- extension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdkl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- negative regulation of axon extension
- regulation of cell cycle
- protein phosphorylation
- positive regulation of dendrite morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein kinase activity
- cyclin-dependent protein kinase activity
- protein serine/threonine kinase activity