Reln Gene Summary [Mouse]
Enables receptor ligand activity; serine-type peptidase activity; and very-low-density lipoprotein particle receptor binding activity. Involved in several processes, including nervous system development; positive regulation of cell communication; and regulation of neurotransmitter receptor activity. Acts upstream of or within several processes, including nervous system development; peptidyl-tyrosine phosphorylation; and regulation of macromolecule metabolic process. Located in cytoplasm; dendrite; and extracellular matrix. Is active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in Norman-Roberts syndrome; autistic disorder; and familial temporal lobe epilepsy 7. Orthologous to human RELN (reelin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Reln |
| Official Name | reelin [Source:MGI Symbol;Acc:MGI:103022] |
| Ensembl ID | ENSMUSG00000042453 |
| Bio databases IDs | |
| Aliases | reelin |
| Synonyms | ETL7, LIS2, PRO1598, Reelen, reeler, REELIN, RL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Reln often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tandem repeat subunit of reelin and related proteins
- Reeler domain
- peptidase
- Domains similar to the eukaryotic reeler domain and bacterial cohesins
- central domain
- protein binding
- receptor binding
- Reelin repeat
- EGF_CA
- serine-type peptidase
- homopolymerization domain
- receptor agonist activity
- Tenascin EGF domain
Pathways
Biological processes and signaling networks where the Reln gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- non-insulin-dependent diabetes mellitus
- metastasis
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- lissencephaly Norman-Roberts type
- rheumatoid arthritis
- venous thromboembolism
- glioblastoma
role in cell
- quantity
- expression in
- formation
- growth
- phosphorylation in
- differentiation
- binding in
- accumulation
- migration
- branching
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- Cytoplasm
- cell surface
- cell borders
- perinuclear region
- Nucleus
- synapse
- extracellular matrix
- perikaryon
- axons
- dendrites
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Reln gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- layer formation in cerebral cortex
- regulation of synaptic activity
- positive regulation of long-term synaptic potentiation
- ventral spinal cord development
- spinal cord patterning
- axon guidance
- cell adhesion
- regulation of neuron differentiation
- associative learning
- regulation of behavior
- response to pain
- neuron migration
- locomotory behavior
- regulation of N-methyl-D-aspartate selective glutamate receptor activity
- postsynaptic density assembly
- positive regulation of neuron projection development
- long-term synaptic potentiation
- positive regulation of synaptic transmission, glutamatergic
- protein localization to synapse
- regulation of neuron migration
- positive regulation of TOR signaling cascade
- positive regulation of peptidyl-tyrosine phosphorylation
- dendrite development
- reelin-mediated signaling pathway
- positive regulation of synapse maturation
- positive regulation of dendritic spine morphogenesis
- cell morphogenesis
- hippocampus development
- cerebral cortex tangential migration
- brain development
- receptor localization to synapse
- long-term memory
- positive regulation of small GTPase mediated signal transduction
- central nervous system development
- positive regulation of protein kinase activity
- N-methyl-D-aspartate receptor clustering
- positive regulation of protein phosphorylation
- proteolysis
- regulation of gene expression
- postsynaptic density protein 95 clustering
- regulation of synaptic transmission
- positive regulation of excitatory postsynaptic membrane potential
- glial cell differentiation
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- dendrite
- extracellular space
- cytoplasm
- extracellular matrix
- extracellular region
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- serine-type peptidase activity
- lipoprotein particle receptor binding
- receptor agonist activity
- very-low-density lipoprotein particle receptor binding