Lrp8

Enables several functions, including amyloid-beta binding activity; apolipoprotein binding activity; and reelin receptor activity. Involved in several processes, including nervous system development; reelin-mediated signaling pathway; and regulation of dendrite development. Acts upstream of or within hippocampus development; layer formation in cerebral cortex; and positive regulation of protein kinase activity. Located in cell surface and extracellular space. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in nervous system and retina layer. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; dementia; myocardial infarction; and schizophrenia. Orthologous to human LRP8 (LDL receptor related protein 8). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrp8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Lrp8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrp8 gene, providing context for its role in the cell.