Abcb4 Gene Summary [Mouse]
Predicted to enable ATPase-coupled transmembrane transporter activity and phosphatidylcholine floppase activity. Involved in bile acid secretion and response to fenofibrate. Located in intercellular canaliculus and plasma membrane. Is expressed in alimentary system and liver. Used to study cholecystitis; cholestasis; hepatocellular carcinoma; intrahepatic cholestasis; and primary sclerosing cholangitis. Human ortholog(s) of this gene implicated in cholestasis (multiple) and liver cirrhosis (multiple). Orthologous to human ABCB4 (ATP binding cassette subfamily B member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abcb4 |
| Official Name | ATP-binding cassette, sub-family B (MDR/TAP), member 4 [Source:MGI Symbol;Acc:MGI:97569] |
| Ensembl ID | ENSMUSG00000042476 |
| Bio databases IDs | |
| Aliases | ATP-binding cassette, sub-family B (MDR/TAP), member 4 |
| Synonyms | ATP-binding cassette, sub-family B member 4, Mdr2, P Glycoprotein 2, Pgy-2 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Abcb4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase activity, coupled to transmembrane movement of substances
- lipid A export permease/ATP-binding protein MsbA
- type I secretion system ABC transporter, PrtD family
- Conjugate Transporter-2 (CT2) Family protein
- nitrate transport ATP-binding subunits C and D
- urea ABC transporter, ATP-binding protein UrtE
- heme ABC exporter, ATP-binding protein CcmA
- ABC transporter transmembrane region
- lipid transporter
- Six-transmembrane helical domain of the ATP-binding cassette transporters
- phosphatidylcholine transporter
- thiol reductant ABC exporter, CydC subunit
- energy-coupling factor transporter ATPase
- nickel import ATP-binding protein NikE
- ABC transporter
- ABC transporter, permease/ATP-binding protein
- P-loop containing Nucleoside Triphosphate Hydrolases
- transporter
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the Abcb4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- TNP-ATP
- NR1I3
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- hypocalcemia
- bleeding
- fibrosis
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
role in cell
- expression in
- growth
- proliferation
- cellular infiltration by
- sensitivity
- survival
- recruitment
- senescence
- abnormal morphology
- infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- Cytoplasm
- cellular membrane
- focal adhesions
- intercellular junctions
- cytosol
- apical cell surfaces
- apical membrane
- Golgi membrane
- nucleoplasm