Sem1 Gene Summary [Mouse]
Acts upstream of or within double-strand break repair via homologous recombination. Predicted to be part of integrator complex and proteasome complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human SEM1 (SEM1 26S proteasome subunit). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sem1 |
| Official Name | SEM1, 26S proteasome complex subunit [Source:MGI Symbol;Acc:MGI:109238] |
| Ensembl ID | ENSMUSG00000042541 |
| Bio databases IDs | |
| Aliases | SEM1, 26S proteasome complex subunit |
| Synonyms | C7orf76, DSS1, ECD, FLJ42280, LOC100506136, LOC679014, PSMD15, SEM1, 26S proteasome complex subunit, SEM1 26S proteasome subunit, SHFD1, SHFDG1, Shfg, SHFM1, SHSF1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sem1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoporosis
- fracture of bone
- bone disorder
regulates
role in cell
- proliferation
- survival
- formation
- homologous recombination in
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sem1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- proteasomal ubiquitin-dependent protein catabolic process
- double-strand break repair via homologous recombination
- proteasome assembly
Cellular Component
Where in the cell the gene product is active
- cytosol
- macromolecular complex
- proteasome complex
- proteasome regulatory particle, lid subcomplex
- integrator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding