Psma2 Gene Summary [Mouse]
Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in P-body. Part of proteasome core complex. Orthologous to human PSMA2 (proteasome 20S subunit alpha 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psma2 |
| Official Name | proteasome subunit alpha 2 [Source:MGI Symbol;Acc:MGI:104885] |
| Ensembl ID | ENSMUSG00000015671 |
| Bio databases IDs | |
| Aliases | proteasome subunit alpha 2 |
| Synonyms | 20S PROTEASOME alpha 2 subunit, 20S PROTEASOME α 2 subunit, HC3, Lmpc3, Macropain subunit C3, MU, PMSA2, proteasome 20S subunit alpha 2, proteasome 20S subunit α 2, PROTEASOME COMPONENT C3, proteasome subunit alpha 2, PROTEASOME subunit alpha type2, proteasome subunit α 2, PROTEASOME subunit α type2, PSC2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psma2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ntn_hydrolase
- proteasome endopeptidase complex
- Proteasome subunit A N-terminal signature
- peptidase
- Proteasome subunit A N-terminal signature Add an annotation
- proteasome endopeptidase complex, archaeal, alpha subunit
- protein binding
- Proteasome subunit
Pathways
Biological processes and signaling networks where the Psma2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic mRNA processing body
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- Nucleus
- cytosol
- nucleoplasm
- clastosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psma2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- response to virus
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- proteasome core complex
- proteasome core complex, alpha-subunit complex
- cytosol
- cytoplasmic mRNA processing body
- proteasome complex
- secretory granule lumen
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding