Stn1 Gene Summary [Mouse]
Enables single-stranded DNA binding activity and telomeric DNA binding activity. Involved in positive regulation of DNA replication. Located in chromosome, telomeric region and nucleus. Part of CST complex. Human ortholog(s) of this gene implicated in melanoma. Orthologous to human STN1 (STN1 subunit of CST complex). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stn1 |
| Official Name | STN1, CST complex subunit [Source:MGI Symbol;Acc:MGI:1915581] |
| Ensembl ID | ENSMUSG00000042694 |
| Bio databases IDs | |
| Aliases | STN1, CST complex subunit |
| Synonyms | 0610009H20Rik, 2310057J23Rik, AAF-44, bA541N10.2, OBFC1, RPA-32, STN1, CST complex subunit, STN1 subunit of CST complex |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CST, complex subunit STN1, C terminal
- single-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- telomeric DNA binding
- oligonucleotide/oligosaccharide-binding fold of replication protein A and class 2b aminoacyl-tRNA synthetases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- prostate cancer
- epithelial cancer
- systemic lupus erythematosus
- insomnia
- chronic obstructive pulmonary disease
- COVID-19
- hypertension
- coronary artery disease
- abdominal aortic aneurysm
role in cell
- cell viability
- accumulation in
- synthesis in
- cohesion
- maintenance
- cohesion in
- camptothecin sensitivity
- integrity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- intermediate filament cytoskeleton
- intracellular membrane-bounded organelle
- nucleoplasm
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- telomere maintenance
- telomere maintenance via telomere lengthening
- positive regulation of DNA replication
- telomere capping
- negative regulation of telomere maintenance via telomerase
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- intermediate filament cytoskeleton
- intracellular membrane-bounded organelle
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- telomeric DNA binding
- single-stranded telomeric DNA binding
- single-stranded DNA binding