Hnrnpf Gene Summary [Mouse]
Predicted to enable TBP-class protein binding activity and single-stranded RNA binding activity. Predicted to be involved in regulation of RNA splicing. Is active in synapse. Is expressed in branchial arch; central nervous system; and sensory organ. Used to study renal glycosuria. Orthologous to human HNRNPF (heterogeneous nuclear ribonucleoprotein F). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hnrnpf |
| Official Name | heterogeneous nuclear ribonucleoprotein F [Source:MGI Symbol;Acc:MGI:2138741] |
| Ensembl ID | ENSMUSG00000042079 |
| Bio databases IDs | |
| Aliases | heterogeneous nuclear ribonucleoprotein F |
| Synonyms | 4833420I20Rik, heterogeneous nuclear ribonucleoprotein F, HnRNP F/H, HNRPF, mcs94-1, OK/SW-cl.23, Ribonucleoprotein F |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hnrnpf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- protein binding
- single-stranded RNA binding
- RNPHF zinc finger
- TATA-binding protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- infection by HIV-1
role in cell
- apoptosis
- migration
- growth
- dipeptide repeat protein sensitivity
- invasion by
- cell cycle progression
- binding in
- processing in
- adipogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- catalytic step 2 spliceosome
- Cytoplasm
- Plasma Membrane
- cytosol
- nuclear pores
- nucleoplasm
- interchromatin granule clusters
- synapse
- detergent-soluble fraction
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hnrnpf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of RNA splicing
- RNA processing
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- membrane
- cytosol
- synapse
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- single-stranded RNA binding