Rad54l Gene Summary [Mouse]
Predicted to enable ATP-dependent DNA/DNA annealing activity and DNA translocase activity. Acts upstream of or within several processes, including determination of adult lifespan; double-strand break repair via homologous recombination; and response to ionizing radiation. Predicted to be located in nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in several structures, including brain ventricular layer; incisor; metencephalon rest of alar plate marginal layer; submandibular gland primordium; and thymus primordium. Used to study sclerocornea. Human ortholog(s) of this gene implicated in breast cancer; disease of cellular proliferation; non-Hodgkin lymphoma; and pancreatic cancer. Orthologous to human RAD54L (RAD54 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Rad54l |
| Official Name | RAD54 like (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:894697] |
| Ensembl ID | ENSMUSG00000028702 |
| Bio databases IDs | |
| Aliases | RAD54 like (S. cerevisiae) |
| Synonyms | hHR54, HR54, hRAD54, RAD54, RAD54A, RAD54 like, RAD54 like (S. cerevisiae) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rad54l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleic acid binding
- DEAD/DEAH box helicase
- SNF2-related domain
- helicase superfamily c-terminal domain
- isomerase
- enzyme
- protein binding
- DNA dependent ATPase
- Helicase conserved C-terminal domain
- single-stranded DNA binding
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal clear cell adenocarcinoma
- breast cancer
- Huntington disease
- urothelial bladder carcinoma
- transitional cell bladder cancer
- gastric epithelial cancer
- hereditary disorder
- epithelial cancer
- hepatoid gastric adenocarcinoma
- hepatocellular carcinoma
role in cell
- cell death
- survival
- formation
- formation in
- function
- sensitivity
- cell survival
- abnormal morphology
- checkpoint recovery in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rad54l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- meiotic cell cycle
- chromatin remodeling
- reciprocal meiotic recombination
- chromosome organization
- determination of adult lifespan
- DNA recombination
- double-strand break repair via synthesis-dependent strand annealing
- response to xenobiotic stimulus
- response to ionizing radiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- metal ion binding
- DNA translocase activity
- helicase activity