SGTB Gene Summary [Human]
Predicted to enable molecular adaptor activity. Predicted to be involved in positive regulation of chaperone-mediated protein folding; posttranslational protein targeting to endoplasmic reticulum membrane; and ubiquitin-dependent ERAD pathway. Predicted to be part of TRC complex. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SGTB |
| Official Name | small glutamine rich tetratricopeptide repeat containing beta [Source:HGNC Symbol;Acc:HGNC:23567] |
| Ensembl ID | ENSG00000197860 |
| Bio databases IDs | |
| Aliases | small glutamine rich tetratricopeptide repeat containing beta, small glutamine rich tetratricopeptide repeat co-chaperone beta |
| Synonyms | C630001O05Rik, SGT2, small glutamine rich tetratricopeptide repeat co-chaperone beta, small glutamine rich tetratricopeptide repeat co-chaperone β, small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta, small glutamine-rich tetratricopeptide repeat (TPR)-containing, β |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SGTB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hsp70 protein binding
- TPR repeat
- Tetratricopeptide repeats
- Homodimerization domain of SGTA
- protein homodimerization
- protein binding
- chaperone binding
- tetratricopeptide repeat
- identical protein binding
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SGTB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein homooligomerization
- protein heterooligomerization
- posttranslational protein targeting to membrane
Cellular Component
Where in the cell the gene product is active
- membrane
- TRC complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- Hsp70 protein binding
- binding, bridging