Aqp11 Gene Summary [Mouse]
Enables water channel activity. Involved in several processes, including intracellular oxygen homeostasis; intracellular water homeostasis; and negative regulation of ERAD pathway. Acts upstream of or within with a positive effect on protein glycosylation. Acts upstream of or within endosomal lumen acidification; kidney development; and water transport. Located in endoplasmic reticulum and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and submandibular gland primordium. Orthologous to human AQP11 (aquaporin 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aqp11 |
| Official Name | aquaporin 11 [Source:MGI Symbol;Acc:MGI:1913583] |
| Ensembl ID | ENSMUSG00000042797 |
| Bio databases IDs | |
| Aliases | aquaporin 11 |
| Synonyms | 1700015P13Rik, AI648923, AQPX1, aquaporin 11, sjds |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aqp11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- channel/pore class transporter
- MIP
- glycerol channel
- inorganic uptake permease
- identical protein binding
- water channel
- transporter
Pathways
Biological processes and signaling networks where the Aqp11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal failure
- growth failure
role in cell
- expression in
- apoptosis
- proliferation
- acidification in
- acidification
- vacuolation
- homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- Endoplasmic Reticulum
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aqp11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- hydrogen peroxide transmembrane transport
- urea transport
- cellular water homeostasis
- glycerol transport
- positive regulation of cell proliferation
- protein glycosylation
- protein homooligomerization
- protein targeting to membrane
- ion transport
- water transport
- proximal tubule development
- endosomal lumen acidification
- negative regulation of epithelial cell proliferation
- oxygen homeostasis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasmic vesicle membrane
- perinuclear region of cytoplasm
- cytoplasm
- intracellular membrane-bounded organelle
- endoplasmic reticulum
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- channel activity
- glycerol channel activity
- water channel activity