Tmem18 Gene Summary [Mouse]
Predicted to enable DNA binding activity. Acts upstream of or within eating behavior and energy homeostasis. Located in nuclear membrane. Is expressed in lower jaw and submandibular gland primordium. Orthologous to human TMEM18 (transmembrane protein 18). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem18 |
| Official Name | transmembrane protein 18 [Source:MGI Symbol;Acc:MGI:2387176] |
| Ensembl ID | ENSMUSG00000043061 |
| Bio databases IDs | |
| Aliases | transmembrane protein 18 |
| Synonyms | BC024093, lncND, transmembrane protein 18 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Transmembrane protein 18
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- energy homeostasis
- cell migration
- eating behavior
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding