Tpk1 Gene Summary [Mouse]
Enables thiamine diphosphokinase activity. Involved in thiamine diphosphate biosynthetic process. Acts upstream of or within thiamine metabolic process. Is active in cytosol. Is expressed in several structures, including gonad; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in inherited metabolic disorder. Orthologous to human TPK1 (thiamin pyrophosphokinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tpk1 |
| Official Name | thiamine pyrophosphokinase [Source:MGI Symbol;Acc:MGI:1352500] |
| Ensembl ID | ENSMUSG00000029735 |
| Bio databases IDs | |
| Aliases | thiamine pyrophosphokinase |
| Synonyms | HTPK1, LOC686257, PP20, thiamine pyrophosphokinase, thiamin pyrophosphokinase 1, THMD5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tpk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Thiamin pyrophosphokinase, catalytic domain
- thiamine pyrophosphokinase
- diphosphotransferase
- thiamine diphosphokinase
- Thiamin pyrophosphokinase, vitamin B1 binding domain
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tpk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- thiamine metabolic process
- thiamine diphosphate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- thiamine diphosphokinase activity
- thiamine binding
- ATP binding
- identical protein binding
- protein binding
- kinase activity