Mmab Gene Summary [Mouse]
Predicted to enable cobalamin binding activity and corrinoid adenosyltransferase activity. Predicted to be involved in cobalamin metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; lung; nervous system; and trophectoderm. Human ortholog(s) of this gene implicated in inherited metabolic disorder and methylmalonic acidemia cblB type. Orthologous to human MMAB (metabolism of cobalamin associated B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mmab |
| Official Name | methylmalonic aciduria (cobalamin deficiency) cblB type homolog (human) [Source:MGI Symbol;Acc:MGI:1924947] |
| Ensembl ID | ENSMUSG00000029575 |
| Bio databases IDs | |
| Aliases | methylmalonic aciduria (cobalamin deficiency) cblB type homolog (human) |
| Synonyms | 9130222L19Rik, ATR, cblB, CFAP23, cob, metabolism of cobalamin associated B, methylmalonic aciduria (cobalamin deficiency) cblB type homolog (human) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mmab often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cob(I)alamin adenosyltransferase
- vitamin binding
- binding protein
- enzyme
- protein binding
- ethanolamine utilization cob(I)yrinic acid a,c-diamide adenosyltransferase EutT
- tetrapyrrole binding
- Non-methyl alkyl or aryl group transferase
- Cobalamin adenosyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hereditary disorder
- methylmalonic aciduria cblB type
- insomnia
- methylmalonic acidemia
- prostate cancer
- prostatic carcinoma
- cataract
- age-related nuclear cataract disorder
- neuroticism
regulates
- cyanocobalamin
- HDL/cholesterol
role in cell
- survival
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mmab gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cobalamin metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- cobalamin binding
- cob(I)yrinic acid a,c-diamide adenosyltransferase activity
- transferase activity, transferring alkyl or aryl (other than methyl) groups