Hic1 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and sequence-specific double-stranded DNA binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of transcription by RNA polymerase II; and positive regulation of DNA damage response, signal transduction by p53 class mediator. Located in chromatin. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and trophectoderm. Used to study Miller-Dieker lissencephaly syndrome. Orthologous to human HIC1 (HIC ZBTB transcriptional repressor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hic1 |
| Official Name | hypermethylated in cancer 1 [Source:MGI Symbol;Acc:MGI:1338010] |
| Ensembl ID | ENSMUSG00000043099 |
| Bio databases IDs | |
| Aliases | hypermethylated in cancer 1 |
| Synonyms | HIC ZBTB transcriptional repressor 1, hypermethylated in cancer 1, LOC100912068, ZBTB29, ZNF901 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hic1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- CtBP binding domain
- transcription regulator
- acetylation site
- BTB_POZ
- histone deacetylase binding
- protein binding
- sequence-specific DNA binding
- C2H2-type zinc finger
- zinc finger
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- transcription repression domain
- double-stranded DNA binding
- Broad-Complex, Tramtrack and Bric a brac
- Zinc-finger double domain
- BTB/POZ domain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- osteoporosis
- hypertension
- metastasis
- breast cancer
- migraines
- venous thromboembolism
- mucopolysaccharidosis type IVB
- Sézary syndrome
role in cell
- apoptosis
- proliferation
- expression in
- activation in
- migration
- cell viability
- invasion
- invasion by
- number
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hic1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of DNA damage response, signal transduction by p53 class mediator
- regulation of transcription, DNA-dependent
- Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
- DNA damage response, signal transduction resulting in induction of apoptosis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- histone deacetylase binding
- metal ion binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity