Clic4 Gene Summary [Mouse]
Predicted to enable chloride channel activity. Involved in keratinocyte differentiation. Acts upstream of or within several processes, including endothelial cell morphogenesis; vacuolar acidification; and vasculature development. Located in mitochondrion. Is expressed in brain; metanephros; skin; and spleen. Orthologous to human CLIC4 (chloride intracellular channel 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clic4 |
| Official Name | chloride intracellular channel 4 (mitochondrial) [Source:MGI Symbol;Acc:MGI:1352754] |
| Ensembl ID | ENSMUSG00000037242 |
| Bio databases IDs | |
| Aliases | chloride intracellular channel 4 (mitochondrial) |
| Synonyms | Chloride intracellular channel 4, CLIC4L, D0Jmb3, H1, huH1, mc3s5, MTCLIC, P64h1, TU-74 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clic4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- Glutathione S-transferase, N-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- binding protein
- cytoplasmic domain
- chloride channel
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- protein binding
- intracellular chloride channel protein
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ovarian cancer
- androgenic alopecia
- ulceration
- cleft lip
- multiple system atrophy
- Hutchinson-Gilford progeria syndrome
- endotoxin shock response
- skin neoplasia
- Merkel-cell carcinoma
- Merkel cell cancer
role in cell
- activation in
- cell death
- transmembrane potential
- apoptosis
- expression in
- quantity
- differentiation
- migration
- production in
- tubulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear membrane fraction
- mitochondrial fraction
- microtubule cytoskeleton
- Cytoplasm
- cell surface
- apical compartment
- perinuclear region
- cellular membrane
- actin cytoskeleton
- Nucleus
- vesicles
- centrosome
- Endoplasmic Reticulum
- Mitochondria
- midbody
- microtubule bundles
- intercellular junctions
- cytosol
- apical cell surfaces
- caveolar membranes
- apical membrane
- trans Golgi network
- mitochondrial membrane
- mitochondrial cristae
- mitochondrial outer membrane
- mitochondrial inner membrane
- nucleoplasm
- nuclear envelope
- nuclear matrix
- neurites
- synaptosomes
- dense-core vesicles
- tight junctions
- microsomal membrane
- microvilli
- filopodia
- perikaryon
- lamellipodia
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Clic4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- establishment or maintenance of apical/basal cell polarity
- multicellular organism growth
- retina vasculature morphogenesis in camera-type eye
- fertilization
- branching morphogenesis of a tube
- vacuolar acidification
- chloride transport
- keratinocyte differentiation
- endothelial cell morphogenesis
- cellular response to calcium ion
- angiogenesis
- regulation of cytoskeleton organization
- cell differentiation
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- plasma membrane
- cell surface
- chloride channel complex
- centrosome
- cytoplasmic vesicle membrane
- extracellular vesicular exosome
- cell-cell junction
- perinuclear region of cytoplasm
- apical part of cell
- microvillus
- cytoplasm
- mitochondrion
- membrane
- actin cytoskeleton
- nuclear matrix
- cytosol
- midbody
Molecular Function
What the gene product does at the molecular level
- protein binding
- chloride channel activity