Meg3 Gene Summary [Mouse]
This gene is paternally-imprinted and thus expressed predominantly from the maternal allele. It generates alternatively-spliced long non protein-coding RNAs that overlap with the microRNAs Mir770 and Mir1906-1. Transcripts from this gene function as negative regulators of growth and may be down-regulated in tumor cells. This gene is expressed in a reciprocal pattern from the nearby Dlk1 (delta-like 1 homolog) gene, which is paternally-expressed. Deletion of this locus disrupts imprinting in this genomic region and results in perinatal morbidity. [provided by RefSeq, Dec 2013]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | Meg3 |
| Official Name | maternally expressed 3 [Source:MGI Symbol;Acc:MGI:1202886] |
| Ensembl ID | ENSMUSG00000021268 |
| Bio databases IDs | |
| Aliases | maternally expressed 3 |
| Synonyms | 2900016C05Rik, 3110050O07Rik, 6330408G06Rik, D12Bwg1266e, FP504, GTL2, LINC00023, maternally expressed 3, NCRNA00023, onco-lncRNA-83, prebp1, PRO0518, PRO2160 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Meg3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- double-stranded DNA binding
- protein binding activity, bridging
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- breast cancer
- respiratory failure
- growth failure
- organismal death
- insulin-dependent diabetes mellitus
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- breast carcinoma
- urothelial bladder carcinoma
role in cell
- expression in
- cell viability
- transcription in
- growth
- proliferation
- phosphorylation in
- production in
- morphology
- activation in
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Meg3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell growth
- gene silencing by miRNA
Cellular Component
Where in the cell the gene product is active
- RNA-induced silencing complex