Arl11 Gene Summary [Mouse]
Predicted to enable GTP binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including clavicle; ganglia; incisor; liver lobe; and telencephalon ventricular layer. Orthologous to human ARL11 (ARF like GTPase 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arl11 |
| Official Name | ADP-ribosylation factor-like 11 [Source:MGI Symbol;Acc:MGI:2444054] |
| Ensembl ID | ENSMUSG00000043157 |
| Bio databases IDs | |
| Aliases | ADP-ribosylation factor-like 11 |
| Synonyms | ADP-ribosylation factor-like 11, ARF like GTPase 11, ARLTS1, C730007L20RIK |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arl11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sar1p-like members of the Ras-family of small GTPases
- ADP-ribosylation factor family
- 50S ribosome-binding GTPase
- Rab subfamily of small GTPases
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- lung carcinoma
- lung carcinoma process
role in cell
- differentiation
- production in
- formation
- apoptosis
- degradation in
- growth
- phosphorylation in
- formation in
- replication in
- replication
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arl11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- intracellular protein transport
- hemopoietic progenitor cell differentiation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity