ARL11 Gene Summary [Human]
This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded protein may play a role in apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been associated with some familial cancers. [provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | ARL11 |
| Official Name | ADP ribosylation factor like GTPase 11 [Source:HGNC Symbol;Acc:HGNC:24046] |
| Ensembl ID | ENSG00000152213 |
| Bio databases IDs | |
| Aliases | ADP ribosylation factor like GTPase 11, ADP-ribosylation factor-like tumor suppressor gene 1 |
| Synonyms | ADP-ribosylation factor-like 11, ARF like GTPase 11, ARLTS1, C730007L20RIK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARL11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sar1p-like members of the Ras-family of small GTPases
- ADP-ribosylation factor family
- 50S ribosome-binding GTPase
- Rab subfamily of small GTPases
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- lung carcinoma
- lung carcinoma process
role in cell
- differentiation
- production in
- formation
- apoptosis
- degradation in
- growth
- phosphorylation in
- formation in
- replication in
- replication
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARL11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- intracellular protein transport
- hemopoietic progenitor cell differentiation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity