U2af2 Gene Summary [Mouse]
Enables C2H2 zinc finger domain binding activity. Involved in RNA splicing. Predicted to be located in nucleus. Predicted to be part of Prp19 complex; U2-type spliceosomal complex; and U2AF complex. Predicted to be active in nuclear speck. Is expressed in several structures, including central nervous system; gut; liver lobe; lower urinary tract; and nose. Human ortholog(s) of this gene implicated in developmental delay, dysmorphic facies, and brain anomalies. Orthologous to human U2AF2 (U2 small nuclear RNA auxiliary factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | U2af2 |
| Official Name | U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 [Source:MGI Symbol;Acc:MGI:98886] |
| Ensembl ID | ENSMUSG00000030435 |
| Bio databases IDs | |
| Aliases | U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 |
| Synonyms | DEVDFB, LOC690372, U2AF65, U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2, U2 small nuclear RNA auxiliary factor 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse U2af2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- arginine serine dipeptide repeat domain
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- pre-mRNA 3' splice site binding
- enzyme binding
- protein domain specific binding
- Occluded RNA-recognition motif
- protein binding
- U2 snRNP auxilliary factor, large subunit, splicing factor
- RNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- melanoma cancer
- developmental delay, dysmorphic facies, and brain anomalies
- insomnia
- hereditary disorder
- organismal death
- leukodystrophy
- metastasis
- metastatic melanoma
- metastatic melanoma cancer
- neurodevelopmental disorder
role in cell
- cell viability
- activation in
- cell death
- migration
- replication in
- survival
- formation
- formation in
- splicing in
- splicing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- spliceosomes
- nucleoplasm
- nucleoli
- interchromatin granule clusters
- nuclear speckles
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse U2af2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of RNA splicing
- negative regulation of nuclear mRNA splicing, via spliceosome
- mRNA processing
- negative regulation of protein ubiquitination
- spliceosomal complex assembly
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- commitment complex
- nucleus
- nuclear speck
- spliceosomal complex
- U2-type prespliceosome
- Prp19 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- pre-mRNA 3'-splice site binding
- poly-pyrimidine tract binding
- C2H2 zinc finger domain binding
- enzyme binding