Retsat Gene Summary [Mouse]
Enables all-trans-retinol 13,14-reductase activity. Involved in retinol metabolic process. Located in endoplasmic reticulum membrane and nuclear outer membrane. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human RETSAT (retinol saturase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Retsat |
| Official Name | retinol saturase (all trans retinol 13,14 reductase) [Source:MGI Symbol;Acc:MGI:1914692] |
| Ensembl ID | ENSMUSG00000056666 |
| Bio databases IDs | |
| Aliases | retinol saturase (all trans retinol 13,14 reductase) |
| Synonyms | 0610039N19RIK, C80029, MMT-7, Pip92, Ppsig, retinol saturase, retinol saturase (all trans retinol 13,14 reductase), Rmt7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Retsat often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- phytoene desaturase
- CH-CH group oxidoreductase
- NAD(P)-binding Rossmann-like domain
- enzyme
- Flavin containing amine oxidoreductase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- organismal death
- diminished ovarian reserve
- early onset hypertension
role in cell
- apoptosis
- survival
- ceralasertib resistance
- berzosertib resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- endoplasmic reticulum membrane
- outer nuclear membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Retsat gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retinol metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear membrane
- membrane
- nuclear outer membrane
Molecular Function
What the gene product does at the molecular level
- all-trans-retinol 13,14-reductase activity