Taok2 Gene Summary [Mouse]
Enables neuropilin binding activity. Involved in neuron projection morphogenesis; positive regulation of JNK cascade; and regulation of actin cytoskeleton organization. Located in axonal growth cone and dendritic growth cone. Colocalizes with actin cytoskeleton. Is expressed in central nervous system and retina. Orthologous to human TAOK2 (TAO kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Taok2 |
| Official Name | TAO kinase 2 [Source:MGI Symbol;Acc:MGI:1915919] |
| Ensembl ID | ENSMUSG00000059981 |
| Bio databases IDs | |
| Aliases | TAO kinase 2 |
| Synonyms | 1110033K02RIK, B230344N16, LOC107987231, MAP3K17, mKIAA0881, PRO7431, PSK, PSK1, PSK1-alpha, PSK1-α, TAO1, TAO2, Tao2beta, TAO kinase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Taok2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase binding
- catalytic domain
- ATP-binding domain
- caspase recognition motif
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- receptor binding
- Protein kinase domain
- MAP kinase kinase kinase
- kinase
- protein kinase activator
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Trichohyalin-plectin-homology domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- schizophrenia
- preeclampsia
- osteoarthritis
- metastasis
- hepatocellular carcinoma
- insomnia
- COVID-19
- bipolar disorder
role in cell
- binding in
- phosphorylation in
- activation in
- formation
- activation
- adhesion
- assembly
- blebbing
- organization
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- axon component
- perinuclear region
- postsynaptic region
- cellular membrane
- actin cytoskeleton
- Nucleus
- microtubules
- cytosol
- nucleoplasm
- nucleoli
- neurites
- cytoplasmic vesicles
- axons
- dendrites
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Taok2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- mitotic cell cycle G2/M transition DNA damage checkpoint
- protein autophosphorylation
- positive regulation of MAPK cascade
- response to DNA damage stimulus
- protein phosphorylation
- protein targeting to membrane
- positive regulation of protein autophosphorylation
- regulation of actin cytoskeleton organization
- regulation of cell growth
- axonogenesis
- positive regulation of JNK cascade
- apoptotic process
- activation of protein kinase activity
- focal adhesion assembly
- cell migration
- actin cytoskeleton organization
- positive regulation of stress-activated MAPK cascade
- stress-activated MAPK cascade
Cellular Component
Where in the cell the gene product is active
- receptor complex
- nucleolus
- neuron projection
- nucleoplasm
- dendritic growth cone
- cytoplasmic vesicle membrane
- axonal growth cone
- cytoplasm
- actin cytoskeleton
- cytosol
- cytoplasmic vesicle
- axon
Molecular Function
What the gene product does at the molecular level
- tau-protein kinase activity
- ATP binding
- protein binding
- protein serine/threonine kinase activator activity
- tau protein binding
- MAP kinase kinase kinase activity
- protein serine/threonine kinase activity
- mitogen-activated protein kinase kinase binding