Med26 Gene Summary [Mouse]
Predicted to enable transcription coregulator activity. Predicted to be involved in positive regulation of gene expression and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Is expressed in several structures, including central nervous system; limb; retina; and tongue. Orthologous to human MED26 (mediator complex subunit 26). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Med26 |
| Official Name | mediator complex subunit 26 [Source:MGI Symbol;Acc:MGI:1917875] |
| Ensembl ID | ENSMUSG00000045248 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 26 |
| Synonyms | 5730493L18Rik, CRSP7, CRSP70, MED70, mediator complex subunit 26, Slc35e1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Med26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- TFIIS helical bundle-like domain
- Mediator complex subunit 26 middle domain
- TFIIS_I
- transcription cofactor
- Mediator complex subunit 26 C-terminal
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- hepatitis A
- allergic rhinitis
- productive infection by HIV-1
regulated by
- STK11
- MEL cells
- hematopoietic progenitor cells
- T lymphocytes
- vorinostat
- romidepsin
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
role in cell
- replication in
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Med26 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- positive regulation of gene expression
- transcription initiation from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- core mediator complex
- mediator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription cofactor activity
- protein binding
- transcription coactivator activity