MED26 Gene Summary [Human]
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | MED26 |
| Official Name | mediator complex subunit 26 [Source:HGNC Symbol;Acc:HGNC:2376] |
| Ensembl ID | ENSG00000105085 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 26 |
| Synonyms | 5730493L18Rik, CRSP7, CRSP70, MED70, mediator complex subunit 26, Slc35e1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MED26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- TFIIS helical bundle-like domain
- Mediator complex subunit 26 middle domain
- TFIIS_I
- transcription cofactor
- Mediator complex subunit 26 C-terminal
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- hepatitis A
- allergic rhinitis
- productive infection by HIV-1
regulated by
- STK11
- MEL cells
- hematopoietic progenitor cells
- T lymphocytes
- vorinostat
- romidepsin
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
role in cell
- replication in
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MED26 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- positive regulation of gene expression
- transcription initiation from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- core mediator complex
- mediator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription cofactor activity
- protein binding
- transcription coactivator activity