Adra2c Gene Summary [Mouse]
Enables G protein-coupled receptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in axon terminus; cytoplasm; and neuronal cell body. Predicted to be active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including adrenal gland; central nervous system; early embryo; oocyte; and sensory organ. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human ADRA2C (adrenoceptor alpha 2C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adra2c |
| Official Name | adrenergic receptor, alpha 2c [Source:MGI Symbol;Acc:MGI:87936] |
| Ensembl ID | ENSMUSG00000045318 |
| Bio databases IDs | |
| Aliases | adrenergic receptor, alpha 2c |
| Synonyms | [a]2C, ADRA2L2, ADRA2RL2, ADRARL2, adrenergic receptor, alpha 2c, adrenergic receptor, α 2c, adrenoceptor alpha 2C, adrenoceptor α 2C, alpha2C, alpha2-C4, alpha-2C adrenergic receptor, alpha2C-ANRENOCEPTOR, ALPHA2CAR, α-2C adrenergic receptor, α 2C AR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adra2c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- hormone binding
- intracellular loop
- G-protein-coupled receptor binding
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- binding protein
- guanyl-nucleotide exchange factor
- transmembrane domain
- protein homodimerization
- 7 transmembrane receptor (rhodopsin family)
- protein heterodimerization
- alpha2-adrenergic receptor
Pathways
Biological processes and signaling networks where the Adra2c gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dementia
- cognitive impairment
- acute coronary syndrome
- cancer
- ragweed allergy
- animal dander allergy
- bleeding
- ocular itching
- allergic conjunctivitis
- fibromyalgia
role in cell
- activation in
- differentiation
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- intracellular compartment
- Cytoplasm
- cell surface
- intracellular space
- perinuclear region
- cellular membrane
- endosomes
- Endoplasmic Reticulum
- postsynaptic membrane
- synaptic membrane
- basolateral membrane
- perikaryon
- axons
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adra2c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- cell-cell signaling
- positive regulation of neuron differentiation
- positive regulation of MAPK cascade
- regulation of smooth muscle contraction
- adenylate cyclase-activating adrenergic receptor signaling pathway
- receptor transactivation
- adrenergic receptor signaling pathway
- negative regulation of norepinephrine secretion
- platelet activation
- negative regulation of epinephrine secretion
- regulation of vasoconstriction
- activation of protein kinase B activity
Cellular Component
Where in the cell the gene product is active
- endosome
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- epinephrine binding
- protein binding
- protein homodimerization activity
- protein heterodimerization activity
- alpha2-adrenergic receptor activity
- alpha-2A adrenergic receptor binding