Tssk2 Gene Summary [Mouse]
Enables magnesium ion binding activity and protein serine/threonine kinase activity. Involved in peptidyl-serine phosphorylation and spermatid development. Located in acrosomal vesicle and centriole. Is expressed in embryo; seminiferous tubule; spermatid; and testis. Orthologous to human TSSK2 (testis specific serine kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tssk2 |
| Official Name | testis-specific serine kinase 2 [Source:MGI Symbol;Acc:MGI:1347559] |
| Ensembl ID | ENSMUSG00000045521 |
| Bio databases IDs | |
| Aliases | testis-specific serine kinase 2 |
| Synonyms | DGS-G, SPOGA2, STK22B, testis-specific serine kinase 2, TSK2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tssk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- binding protein
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- Protein kinase domain
- magnesium ion binding
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centriole
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tssk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatid development
- protein autophosphorylation
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- centriole
- acrosomal vesicle
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein binding
- protein serine/threonine kinase activity