Chrm2 Gene Summary [Mouse]
Enables G protein-coupled acetylcholine receptor activity. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within G protein-coupled acetylcholine receptor signaling pathway. Is active in cholinergic synapse. Is expressed in several structures, including alimentary system; central nervous system; heart; sublingual gland primordium; and trigeminal nerve. Human ortholog(s) of this gene implicated in several diseases, including Chagas disease; bipolar disorder; heroin dependence; major depressive disorder; and schizophrenia. Orthologous to human CHRM2 (cholinergic receptor muscarinic 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chrm2 |
| Official Name | cholinergic receptor, muscarinic 2, cardiac [Source:MGI Symbol;Acc:MGI:88397] |
| Ensembl ID | ENSMUSG00000045613 |
| Bio databases IDs | |
| Aliases | cholinergic receptor, muscarinic 2, cardiac |
| Synonyms | AChR-M2, Acm2, cholinergic receptor muscarinic 2, cholinergic receptor, muscarinic 2, cholinergic receptor, muscarinic 2, cardiac, HM2, LOC100912433, M2, M2ACHR, M2 MACHR, M2 MUSCARINIC receptor, M2R |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chrm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled acetylcholine receptor
- intracellular loop
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- phosphorylation site
Pathways
Biological processes and signaling networks where the Chrm2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- therapy-associated diarrhea
- major depression
- bipolar I disorder
- Parkinson disease
- bipolar disorder
- amyotrophic lateral sclerosis
- ocular hypertension
- open-angle glaucoma
- glaucoma
- diabetes mellitus
role in cell
- phosphorylation in
- binding in
- loss
- synaptic transmission in
- neurotransmission in
- loss in
- transmission
- long-term potentiation in
- short-term potentiation in
- sprouting in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- membrane fraction
- synaptosomal membrane fractions
- glutaminergic synapse
- endocytic vesicle membrane
- Cytoplasm
- cilia
- cell surface
- cell periphery
- perinuclear region
- cellular membrane
- basal bodies
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- cytoplasmic face of plasma membrane
- presynaptic membrane
- postsynaptic membrane
- caveolae
- nucleoli
- neuromuscular junctions
- synapse
- multivesicular bodies
- membrane rafts
- perikaryon
- dendrites
- axon terminals
- presynaptic terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chrm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
- adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
- G-protein coupled receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- regulation of heart contraction
- nervous system development
- G-protein coupled acetylcholine receptor signaling pathway
- synaptic transmission
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- response to virus
- regulation of smooth muscle contraction
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- dendrite
- clathrin-coated endocytic vesicle membrane
- symmetric synapse
- postsynaptic membrane
- membrane
- asymmetric synapse
- synapse
- neuronal cell body
- plasma membrane
- axon terminus
Molecular Function
What the gene product does at the molecular level
- G-protein coupled acetylcholine receptor activity
- serotonin receptor activity