Vwc2l Gene Summary [Mouse]
Acts upstream of or within negative regulation of BMP signaling pathway and positive regulation of neuron differentiation. Located in extracellular space. Part of AMPA glutamate receptor complex. Is expressed in several structures, including central nervous system; gut; hemolymphoid system gland; liver; and lung. Orthologous to human VWC2L (von Willebrand factor C domain containing 2 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vwc2l |
| Official Name | von Willebrand factor C domain-containing protein 2-like [Source:MGI Symbol;Acc:MGI:2444069] |
| Ensembl ID | ENSMUSG00000045648 |
| Bio databases IDs | |
| Aliases | von Willebrand factor C domain-containing protein 2-like |
| Synonyms | A830006F12Rik, Brl, Brorin-l, LOC402117, RGD1565501, von Willebrand factor C domain containing 2 like, von Willebrand factor C domain-containing protein 2-like |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vwc2l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- von Willebrand factor type C domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vwc2l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of BMP signaling pathway
- positive regulation of neuron differentiation
Cellular Component
Where in the cell the gene product is active
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
- extracellular space
- synapse
Molecular Function
What the gene product does at the molecular level
- protein binding