Otx1 Gene Summary [Mouse]
This gene encodes a member of the bicoid subfamily of the paired homeobox transcription factor family. The encoded protein is critical to the maintenance and regionalization of the forebrain and midbrain during development. It may also have important functions in sense organ development, pituitary function, and in the regulation of blood cell production. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Otx1 |
| Official Name | orthodenticle homeobox 1 [Source:MGI Symbol;Acc:MGI:97450] |
| Ensembl ID | ENSMUSG00000005917 |
| Bio databases IDs | |
| Aliases | orthodenticle homeobox 1 |
| Synonyms | A730044F23Rik, jv, LOC100364498, orthodenticle homeobox 1, OTX1X |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Otx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- Otx1 transcription factor
- protein binding
- sequence-specific DNA binding
- homeodomain
Pathways
Biological processes and signaling networks where the Otx1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rectum cancer
- breast cancer
- lung adenocarcinoma
- liver cancer
- epithelial cancer
- neoplasia
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- hepatocellular carcinoma
- epileptic seizure
role in cell
- expression in
- apoptosis
- proliferation
- migration
- phosphorylation in
- differentiation
- invasion by
- retraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Otx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- midbrain development
- diencephalon morphogenesis
- inner ear morphogenesis
- anterior/posterior pattern specification
- positive regulation of transcription from RNA polymerase II promoter
- metencephalon development
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity