Pid1 Gene Summary [Mouse]
Involved in several processes, including cellular response to cytokine stimulus; negative regulation of D-glucose import; and positive regulation of ATP biosynthetic process. Located in cytoplasm. Is expressed in genitourinary system and retina. Orthologous to human PID1 (phosphotyrosine interaction domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pid1 |
| Official Name | phosphotyrosine interaction domain containing 1 [Source:MGI Symbol;Acc:MGI:2138391] |
| Ensembl ID | ENSMUSG00000045658 |
| Bio databases IDs | |
| Aliases | phosphotyrosine interaction domain containing 1 |
| Synonyms | 5033414K04Rik, Ab1-119, FLJ20701, HMFN2073, NYGGF4, P-CLI1, phosphotyrosine interaction domain containing 1, RGD1560766 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pid1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Pleckstrin homology-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- coronary artery disease
- angina pectoris
- Alzheimer disease
- juvenile rheumatoid arthritis
- gastroesophageal reflux
- myocardial infarction
- corneal neovascularization
- lagophthalmos
- Moyamoya disease
role in cell
- proliferation
- organization
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pid1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of ATP biosynthetic process
- positive regulation of ATP biosynthetic process
- negative regulation of glucose import
- energy reserve metabolic process
- fat cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of insulin receptor signaling pathway
- mitochondrion organization
- cellular response to fatty acid
- cellular response to interleukin-6
- regulation of mitochondrial membrane potential
- positive regulation of gene expression
- cellular response to leptin stimulus
- negative regulation of protein phosphorylation
- positive regulation of fat cell proliferation
- regulation of reactive oxygen species metabolic process
- regulation of mitochondrial fusion
- cellular response to cytokine stimulus
- cellular response to tumor necrosis factor
- positive regulation of reactive oxygen species metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding