Rbm15 Gene Summary [Mouse]
Enables RNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome and thrombopoietin-mediated signaling pathway. Acts upstream of or within several processes, including circulatory system development; regulation of transcription by RNA polymerase II; and spleen development. Located in nucleus. Is expressed in several structures, including brain; olfactory epithelium; retina; thymus; and trophectoderm. Orthologous to human RBM15 (RNA binding motif protein 15). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rbm15 |
| Official Name | RNA binding motif protein 15 [Source:MGI Symbol;Acc:MGI:2443205] |
| Ensembl ID | ENSMUSG00000048109 |
| Bio databases IDs | |
| Aliases | RNA binding motif protein 15 |
| Synonyms | C230088J01RIK, mKIAA1438, OTT, OTT1, RNA binding motif protein 15, SPEN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rbm15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPOC (Spen paralog and ortholog C-terminal) domain superfamily
- RNA recognition motif (RRM) superfamily
- Spen paralog and ortholog C-terminal domain
- RNA recognition motif
- mRNA binding
- SPOC domain
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- melanoma cancer
- cervical cancer
- colorectal cancer
- pancreatic cancer
- soft tissue sarcoma cancer
- pulmonary hypertensive arterial disease
- organismal death
- glioblastoma
- glioblastoma cancer
- neuroblastoma
role in cell
- proliferation
- quantity
- differentiation
- G2/M phase
- expansion
- alternative splicing by
- splicing in
- signaling in
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spliceosomes
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rbm15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of myeloid cell differentiation
- placenta blood vessel development
- spleen development
- positive regulation of transcription of Notch receptor target
- regulation of megakaryocyte differentiation
- dosage compensation by inactivation of X chromosome
- thrombopoietin-mediated signaling pathway
- ventricular septum morphogenesis
- RNA methylation
- negative regulation of transcription, DNA-dependent
- patterning of blood vessels
- regulation of alternative nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- nuclear speck
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding