Fbxl12 Gene Summary [Mouse]
Acts upstream of or within ubiquitin-dependent protein catabolic process. Located in cytoplasm. Part of ubiquitin ligase complex. Is expressed in cerebral cortex ventricular layer; chorioallantoic placenta; cortical plate; decidua; and embryo. Orthologous to human FBXL12 (F-box and leucine rich repeat protein 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxl12 |
| Official Name | F-box and leucine-rich repeat protein 12 [Source:MGI Symbol;Acc:MGI:1354738] |
| Ensembl ID | ENSMUSG00000066892 |
| Bio databases IDs | |
| Aliases | F-box and leucine-rich repeat protein 12 |
| Synonyms | 3110048D16Rik, Fbl12, F-box and leucine-rich repeat protein 12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbxl12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- F-box domain superfamily
- F-box
- F-box-like
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbxl12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytosol
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein binding