Amigo1 Gene Summary [Mouse]
Enables potassium channel regulator activity. Involved in positive regulation of potassium ion transmembrane transport. Acts upstream of or within positive regulation of synapse assembly. Located in dendrite and neuronal cell body membrane. Part of voltage-gated potassium channel complex. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; gut; and sensory organ. Orthologous to human AMIGO1 (adhesion molecule with Ig like domain 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Amigo1 |
| Official Name | adhesion molecule with Ig like domain 1 [Source:MGI Symbol;Acc:MGI:2653612] |
| Ensembl ID | ENSMUSG00000050947 |
| Bio databases IDs | |
| Aliases | adhesion molecule with Ig like domain 1 |
| Synonyms | adhesion molecule with Ig like domain 1, ALI2, AMIGO |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Amigo1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunoglobulin domain
- potassium channel regulator
- Immunoglobulin like
- Leucine rich repeat
- Immunoglobulin I-set domain
- protein binding
- Leucine rich repeat N-terminal domain
- Leucine Rich repeats (2 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Amigo1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of axonogenesis
- axonogenesis
- heterophilic cell-cell adhesion
- myelination
- positive regulation of neuron projection development
- homophilic cell adhesion
- brain development
- positive regulation of synapse assembly
- axonal fasciculation
Cellular Component
Where in the cell the gene product is active
- dendrite
- voltage-gated potassium channel complex
- membrane
- neuronal cell body membrane
- perikaryon
Molecular Function
What the gene product does at the molecular level
- protein binding
- potassium channel regulator activity