Dlk1 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity. Involved in negative regulation of fat cell differentiation and negative regulation of vascular endothelial cell proliferation. Acts upstream of or within several processes, including bone mineralization; negative regulation of Notch signaling pathway; and positive regulation of bone resorption. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and musculoskeletal system. Orthologous to human DLK1 (delta like non-canonical Notch ligand 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Dlk1 |
| Official Name | delta like non-canonical Notch ligand 1 [Source:MGI Symbol;Acc:MGI:94900] |
| Ensembl ID | ENSMUSG00000040856 |
| Bio databases IDs | |
| Aliases | delta like non-canonical Notch ligand 1 |
| Synonyms | AC165954.1, delta, Delta1, Delta-like 1 homolog, delta like non-canonical Notch ligand 1, DLK, DlkI, FA1, foetal antigen 1, Ly107, Peg9, pG2, PREF1, SCP1, ZOG, δ, δ-like 1 homolog, δ-like dlk homeotic, δ like non-canonical Notch ligand 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dlk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- ectodomain
- intracellular domain
- protein binding
- membrane-proximal domain
- EGF_CA
Pathways
Biological processes and signaling networks where the Dlk1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic steatosis
- hyperlipidemia
- neoplasia
- glioblastoma
- central precocious puberty
- obesity
- growth failure
- bronchiolo-alveolar adenocarcinoma
- broncho-alveolar lung cancer
- hepatic fibrosis
role in cell
- expression in
- activation in
- growth
- formation
- upregulation in
- survival
- phosphorylation in
- production in
- differentiation
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cellular membrane
- Plasma Membrane
- cytosol
- plasma membrane extracellular face
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dlk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell differentiation
- negative regulation of Notch signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding