Gpat2 Gene Summary [Mouse]
Enables 1-acylglycerol-3-phosphate O-acyltransferase activity and glycerol-3-phosphate O-acyltransferase activity. Involved in phosphatidic acid biosynthetic process and piRNA processing. Acts upstream of or within glycerol-3-phosphate metabolic process and triglyceride biosynthetic process. Located in mitochondrion. Is expressed in germ cell of testis; interstitium of the testis; testis; and tunica albuginea of testis. Orthologous to human GPAT2 (glycerol-3-phosphate acyltransferase 2, mitochondrial). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpat2 |
| Official Name | glycerol-3-phosphate acyltransferase 2, mitochondrial [Source:MGI Symbol;Acc:MGI:2684962] |
| Ensembl ID | ENSMUSG00000046338 |
| Bio databases IDs | |
| Aliases | glycerol-3-phosphate acyltransferase 2, mitochondrial |
| Synonyms | A530057A03Rik, CT123, glycerol-3-phosphate acyltransferase 2, mitochondrial, Gm116, RGD1304904, xGPAT1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpat2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
- 1-acylglycerol-3-phosphate O-acyltransferase
- glycerol-3-phosphate O-acyltransferase
- enzyme
- protein binding
- Acyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpat2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycerol-3-phosphate metabolic process
- phospholipid biosynthetic process
- triglyceride biosynthetic process
- piRNA metabolic process
- CDP-diacylglycerol biosynthetic process
- fatty acid metabolic process
- phosphatidic acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- mitochondrion
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- 1-acylglycerol-3-phosphate O-acyltransferase activity
- glycerol-3-phosphate O-acyltransferase activity